Figure 5 | Scientific Reports

Figure 5

From: PDGFBB facilitates tumorigenesis and malignancy of lung adenocarcinoma associated with PI3K-AKT/MAPK signaling

Figure 5

A549 cells transfected with HSV-PDGFi-shRNA had a low probability of tumorigenesis in vivo. (A) The representative images showed the tumorigenesis of nude mice in normal-A549 group, vector-A549 group and HSV-PDGFi-shRNA A549 group. (B) The time for normal-A549, vector-A549 and HSV-PDGFi-shRNA A549 to form a visible tumor. (C) The tumor volume from 0 to 9 weeks after A549 cell inoculation. (D) The body weight of nude mice from 0 to 9 weeks after A549 cells inoculation. n = 6–8. *HSV-PDGFi-shRNA group vs vector group, *P < 0.05, **P < 0.01 by one-way ANOVA (B) or/and two-way ANOVA (C, D).

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