Figure 7
PI3K/AKT signaling and Ras/MAPK signaling might be the functional downstream nodes for PDGFBB. (A) The top 10 cellular components of up-regulated DEGs and down-regulated DEGs. (B) The top 10 molecular functions of up-regulated DEGs and down-regulated DEGs. (C) The top 10 biological processes of up-regulated DEGs and down-regulated DEGs. (D) The top 10 enriched KEGG pathways of up-regulated DEGs and down-regulated DEGs. (E, F) The key gene expression of PI3K/AKT signaling and Ras/MAPK signaling in the A549 and SPCA1 cells transfected with HSV-PDGFi-shRNA for 48 h by RT-PCR (n = 4). (G, H) The key gene expression of PI3K/AKT signaling and Ras/MAPK signaling in the A549 and SPCA1 cells administrated with exogenous PDGFBB for 48 h by RT-PCR (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA (E–H).
