Table 2 MIC and toxicity of tested peptides. MIC is determined as the lowest test concentration of peptides for microbial viability less than 10%. EC90 is the highest test concentration of peptides for rabbit red blood cell or HaCaT cell viability higher than 90%. Index is the ratio of EC90 to MIC of C. acnes.
From: Novel antimicrobial peptides against Cutibacterium acnes designed by deep learning
MIC (µg/mL) | Cytotoxic | Hemolysis | ||||||
|---|---|---|---|---|---|---|---|---|
C. acnes | E. coli | S. aureus | C. albicans | EC90 (µg/mL) | Index | EC90 (µg/mL) | Index | |
AMP-5 | 8 | 12.5 | 100 | 12.5 | 80 | 10 | 240 | 30 |
AMP-9 | 8 | 25 | > 100 | 25 | 160 | 20 | 240 | 30 |
AMP-12 | 2 | 8 | 8 | 25 | 32 | 16 | 80 | 40 |
AMP-25 | 4 | 50 | > 100 | 25 | 80 | 20 | 240 | 60 |
AMP-27 | 25 | 100 | > 100 | 50 | > 320 | 12.8 | 160 | 6.4 |
AMP-29 | 2 | 8 | 8 | 25 | 32 | 16 | 64 | 32 |
AMP-31 | 4 | 8 | 8 | 25 | 32 | 8 | 80 | 20 |
AMP-33 | 4 | 25 | 50 | 12.5 | 80 | 20 | 80 | 20 |
AMP-38 | 8 | 8 | 12.5 | 50 | 80 | 10 | 128 | 16 |
HPA3NT3 | 4 | 50 | 100 | 25 | 32 | 8 | 128 | 32 |
FK13 | 4 | 8 | 25 | – | 80 | 20 | 64 | 16 |
