Figure 3

Shows a schematic 3D model of the prostate with the definition of a positive surgical margin (PSM), the proximity of the capsule to prostate cancer, the proportion of positive slides, the percentage of tumor volume (TuVol%) and the definitions of horizontal and vertical tumor extent. Each slice represents a single whole-mount slide. Our analyses with multiple mixed-effects regression models and mediation analyses revealed that the proportion of prostate cancer (PCa)-positive slides and the proximity of the prostate cancer capsule were indicative of the degree to which the tumor grade was concordant between the AI algorithms and pathology reports. While the capsule proximity status was indicative of grade, an increase in the proportion of positive slides was indicative of grade agreement. Because a single radical prostatectomy specimen cannot be embedded into a single block and investigated at once, this specimen was dissected into multiple slices (whole mount). PSM: Positive surgical margins.