Table 1 Clinical characteristics of patients with standard or non-standard initial anti-tuberculosis treatment regimen.
Characteristics | Not standard initial TB treatment (N = 50) | Standard initial TB treatment (N = 50) | p value |
|---|---|---|---|
Age: year | 71.8 ± 15.3 | 71.7 ± 14.9 | 0.989 |
Male gender | 39 (78%) | 39 (78%) | 1.000 |
Smoking | 0.899 | ||
Current smoker | 4 (8%) | 5 (10%) | |
Ex-smoker | 11 (22%) | 12 (24%) | |
BW | 56.0 ± 16.6 | 58.2 ± 14.1 | 0.472 |
BMI | 21.6 ± 4.2 | 22.2 ± 3.3 | 0.484 |
Underlying co-morbid condition | |||
Eye disease | 19 (38%) | 5 (10%) | 0.001 |
DM | 14 (28%) | 10 (20%) | 0.349 |
COPD | 10 (21%) | 8 (16%) | 0.603 |
Chronic lung disease (emphysema excluded) | 6 (12%) | 6 (12%) | 1.000 |
Liver disease | 26 (53%) | 6 (12%) | < 0.001 |
Hepatitis B and C | 15 (30%) | 6 (12%) | 0.027 |
Liver cirrhosis | 5 (10%) | 0(0%) | 0.022 |
Hepatic carcinoma | 1 (2%) | 0 (0%) | 0.315 |
Gout/hyperuricemia | 18 (36%) | 7 (14%) | 0.011 |
ESRD | 4 (8%) | 0 (0%) | 0.041 |
CKD | 8 (16%) | 3 (6%) | 0.110 |
Cancer | 16 (32%) | 8 (16%) | 0.061 |
Remission | 13 (26%) | 8 (16%) | 0.220 |
Active | 3 (6%) | 1 (2%) | 0.307 |
Autoimmune disease | 1 (2%) | 0 | 0.315 |
Post transplantation | 2 (4%) | 0 | 0.153 |
Prior TB history | 3(6%) | 2(4%) | 0.646 |
Laboratory tests | |||
Initial acid-fast smear | 0.038 | ||
Strong: 3+ to 4+ | 2 (4%) | 10 (20%) | |
Weak: 1+ to 2+ | 9 (18%) | 10 (20%) | |
Hemoglobin (g/dL) | 11.1 ± 2.3 | 12.4 ± 2.4 | 0.006 |
AST (U/L) | 43.3 ± 41.5 | 30.3 ± 16.9 | 0.044 |
ALT (U/L) | 40.4 ± 57.0 | 24.3 ± 24.0 | 0.070 |
Total bilirubin (mg/dL) | 1.8 ± 3.6 | 0.7 ± 0.5 | 0.047 |
Treatment duration, days | 281 ± 121 | 223 ± 63 | 0.003 |
Treatment interruption | 13 (26%) | 4 (8%) | 0.021 |
