Figure 2
PenkCre+ cells in the DG have a morphology similar to DGNs born at E14.5. (A) Experimental design. (B) Sparse labeled cells after injection of AAV-hSyn-DIO-mCherry virus into the DG of a PenkCre mouse. (C) Representative tracings of PenkCre+ neurons in the DG of 12 week-old mice. Comparison of (D) the number (Nb) of primary apical dendrites, (E) the total dendritic length, (F) the branching angle and (G) the relative position in the GCL of PenkCre+ neurons with DGNs tagged at E14.5 in Kerloch et al. (2019) with in utero electroporation. PenkCre+ neurons were traced from n = 5 mice (30 neurons in total with a minimum of 3 neurons per animal) and were compared to the DGNs from Kerloch et al. (n = 5 mice) using Mann–Whitney test. Scale bars represent 100 µm (B) and 20 µm (C).
