Table 1 Characteristics at the baseline of the KoGES_Ansan and Ansung dataset.
Total (n = 5490) | PRS Bottom decile (n = 549) | Middle (10–90%) (n = 4392) | PRS Top decile (n = 549) | P-value | |
|---|---|---|---|---|---|
Basic information | |||||
Male (%) | 2614 (47.61) | 267 (48.63) | 2069 (47.11) | 278 (50.64) | 0.260 |
Age (year) | 51.54 \(\pm\) 8.50 | 51.63 \(\pm \; 8.51\) | 51.50 \(\pm \;8.46\) | 51.77 \(\pm \; 8.81\) | 0.707 |
Physical measurements | |||||
BMI (kg/m2) | 24.63 \(\pm\) 3.04 | 24.51 \(\pm\) 3.09 | 24.64 \(\pm \; 3.06\) | 24.70 \(\pm \; 2.85\) | 0.550 |
SBP (mmHg) | 120.87 \(\pm\) 17.94 | 119.85 \(\pm \; 17.66\) | 120.83 \(\pm \; 18.00\) | 122.26 \(\pm \; 17.70\) | 0.078 |
DBP (mmHg) | 80.14 \(\pm\) 11.22 | 80.01 \(\pm \; 11.11\) | 80.10 \(\pm\; 11. 23\) | 80.58 \(\pm \;11.29\) | 0.620 |
Clinical risk factors | |||||
HDL (mg/dL) | 49.29 \(\pm\) 11.52 | 50.01 \(\pm \; 11.88\) | 49.32 \(\pm \; 11.52\) | 48.39 \(\pm\; 11.11\) | 0.063 |
LDL (mg/dL) | 119.55 \(\pm\) 33.01 | 117.61 \(\pm \; 30.82\) | 119.78 \(\pm \; 33.14\) | 119.72 \(\pm \; 34.05\) | 0.348 |
TG (mg/dL) | 152.90 \(\pm\) 110.20 | 140.93 \(\pm \; 96.15\) | 152.93 \(\pm \; 111.57\) | 164.64 \(\pm\; 111.17\) | 1.72E−03 |
Fasting glucose (mg/dL) | 92.14 \(\pm\) 21.14 | 86.58 \(\pm \; 11.47\) | 91.65 \(\pm \;19.65\) | 102.32 \(\pm \;35.03\) | < 2.00E−16 |
Fasting insulin (\(\upmu\)IU/Ml) | 7.54 \(\pm\) 4.48 | 7.23 \(\pm \;3.78\) | 7.57 \(\pm \;4.46\) | 7.63 \(\pm \;5.21\) | 0.212 |
HbA1c (%) | 5.77 \(\pm\) 0.90 | 5.47 \(\pm \; 0.48\) (36 mmol/mol) | 5.75 \(\pm \; 0.85\) (39 mmol/mol) | 6.25 \(\pm \; 1.35\) (45 mmol/mol) | < 2.00E−16 |
Others | |||||
Current smoking (%) | 1295 (23.59) | 134 (24.42) | 1025 (23.38) | 136 (24.77) | 0.727 |
Family history (%) | 651 (11.86) | 40 (7.29) | 508 (11.57) | 103 (18.76) | 1.20E−08 |
Physical activity (%) | 1981 (36.08) | 190 (34.70) | 1588 (36.15) | 203 (36.98) | 0.591 |
Type 2 diabetes mellitus | |||||
Case (%) | 746 (13.59) | 20 (3.64) | 549 (12.5) | 177 (32.24) | < 2.00E−16 |
