Table 3 Results of Cox regression analysis for predicting insulin prescription and T2DM complications.

From: The clinical relevance of a polygenic risk score for type 2 diabetes mellitus in the Korean population

Prediction

PRS

Hazard ratio

95% CI

P-value

Insulin prescription

Categorized PRS

   

Remaining

1.00 (reference)

  

Top decile

1.692

1.075–2.662

0.0231

Standardized PRS

1.663

1.331–2.077

7.61E−06

T2DM complications

Categorized PRS

   

Bottom decile

0.7841

0.4290–1.433

0.429

Middle (10–90%)

1.00 (reference)

  

Top decile

0.8992

0.6900–1.172

0.432

Standardized PRS

0.9878

0.8910–1.095

0.816

  1. Cox regression model was used with sex and time from T2DM diagnosis to insulin prescription or T2DM complications in a year. For the insulin prescription prediction, participants were classified into two groups according to a percentile of PRS: top decile and remaining (\(\le\) 90%). T2DM complications include myocardial infarction, coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral artery disease, and kidney disease. T2DM: type 2 diabetes mellitus.
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