Figure 4
From: MAX controls meiotic entry in sexually undifferentiated germ cells
Apoptotic phenotype of primordial germ cells undergoing forced meiosis by Max ablation. (A, B) Total germ cell numbers assessed by TRA98 staining in gonads of M, MC, F, and FC mouse embryos at E12.5 (A) and E14.5 (B). (C) Percentages of cleaved-PARP-positive germ cells in gonads of M, MC, F, and FC mice at E14.5. (D) Proportions of germ cells in meiotic prophase l in E18.5 gonads of F and FC embryos. Germ cells were immunostained for SYCP3 after spreading onto a glass slide and their meiotic stages were classified as described in Fig. 2F.
