Figure 5
Tumor slice culture treatment with anti-PD-1 and anti-IL-10. (A) Representative 20 × fields of tumor slices from patient 10 stained for cleaved-Caspase-3 (cC3) after treatment with IgG mAb control, anti-PD-1 mAb, anti-IL-10 mAb, and anti-PD-1 mAb + anti-IL-10 mAb. (B) Average % cC3 raw positivity by treatment group for all patients combined. Each circle represents the difference compared to control in mean % cC3 + cells of three slice replicates per treatment group for a unique tumor (n = 5 for all except the aPD-1 and aIL-10 group where n = 4). The lines connect mean % cC3 + for each patient. Mann–Whitney U test.
