Table 3 The most potential HTL epitopes with interacting MHC-II alleles and population coverage.
No | CD4 + T Cell epitopes | Length | Start | End | MHC-II binding alleles | Percentile rank | Smm IC50 | Population coverage | ||
|---|---|---|---|---|---|---|---|---|---|---|
World | Europe | Southwest Asia | ||||||||
1 | NRPTITFAGTAAEFG | 15 | 101 | 115 | HLA-DQA1*04:01/DQB1*04:02 | 0.23 | 159 | 79.44% | 75.61% | 76.82% |
HLA-DQA1*03:01/DQB1*03:02 | 1.3 | 418 | ||||||||
HLA-DQA1*05:01/DQB1*02:01 | 3.2 | 571 | ||||||||
2 | KNRPTITFAGTAAEF | 15 | 100 | 114 | HLA-DQA1*04:01/DQB1*04:02 | 0.26 | 155 | 82.76% | 77.22% | 77.92% |
HLA-DQA1*03:01/DQB1*03:02 | 1.5 | 464 | ||||||||
HLA-DQA1*05:01/DQB1*03:01 | 7.2 | 71 | ||||||||
3 | GTVDFIFGEARSLYL | 15 | 192 | 206 | HLA-DRB1*07:01 | 0.28 | 11 | 85.73 | 98.31% | 84.82% |
HLA-DRB1*09:01 | 2 | 97 | ||||||||
HLA-DRB1*01:01 | 5.4 | 30 | ||||||||
HLA-DRB1*03:01 | 5.9 | 362 | ||||||||
HLA-DRB5*01:01 | 8.5 | 59 | ||||||||
HLA-DPA1*01:03/DPB1*04:01 | 9 | 454 | ||||||||
4 | GANLIVSNSAPRPDG | 15 | 131 | 145 | HLA-DRB3*02:02 | 0.52 | 53 | 55.65% | 48.36% | 48.11% |
HLA-DRB1*13:02 | 1.4 | 5.4 | ||||||||
HLA-DRB1*03:01 | 4.7 | 114.4 | ||||||||
HLA-DRB1*09:01 | 6.4 | 581 | ||||||||
5 | AKTFTSLEYIEAAKW | 15 | 318 | 332 | HLA-DPA1*01:03/DPB1*04:01 | 0.68 | 98 | 81.44% | 97.02% | 23.74% |
HLA-DPA1*03:01/DPB1*04:02 | 1.9 | 864 | ||||||||
HLA-DPB1*02:01 | 3.4 | 345 | ||||||||
6 | LGRAWFEAARVVFSY | 15 | 251 | 265 | HLA-DPA1*02:01/DPB1*14:01 | 0.76 | 100 | 91.74% | 92.75% | 88.43% |
HLA-DQA1*01:02/DQB1*06:02 | 0.97 | 79 | ||||||||
HLA-DQA1*05:01/DQB1*03:01 | 3.3 | 37 | ||||||||
HLA-DPB1*05:01 | 6.1 | 245 | ||||||||
HLA-DRB1*09:01 | 6.6 | 208 | ||||||||
7 | EFGTVDSATLIVESD | 15 | 113 | 127 | HLA-DQA1*04:01/DQB1*04:02 | 0.78 | 340 | 77.41% | 7.86% | 65.00% |
HLA-DQA1*01:02/DQB1*06:02 | 1.8 | 111 | ||||||||
HLA-DQA1*03:01/DQB1*03:02 | 2 | 209 | ||||||||
8 | GRAWFEAARVVFSYC | 15 | 252 | 266 | HLA-DQA1*01:02/DQB1*06:02 | 0.98 | 80 | 82.00% | 81.00% | 73.34% |
HLA-DPA1*02:01/DPB1*14:01 | 1.2 | 98 | ||||||||
9 | AELESWFQGAVKPVS | 15 | 8 | 22 | HLA-DQA1*01:01/DQB1*05:01 | 3.4 | 847 | 31.46% | 32.82% | 35.61% |