Figure 1

miRNA-SV2B interactions. (a) KEGG pathway analysis depicted the most differentially expressed miRNAs profiles in 529 GBM cases (grade 4). miR-21 and miR-221 (red boxes) were seen to be upregulated, whereas miR-34a and miR-128 (blue boxes) were downregulated. (b) miR-34a was depicted as one of the most important miRNAs involved in the overall gene regulation for SV2B co-expressed genes (HRNBP3, SULT4A1, SLC12A5, PACSIN1, GRIN1, VSNL1, PHYHIP, SYN2, CAMK2A, GLS2, NCDN, NRGN, SYT1, AK5, NAPB). (c) miR-128a was observed to be one of the most important brain specific miRNAs regarding gene hub associated with SV2B. (d) miR-34a-5p was identified as downregulated and depicted as a main target for SV2B out of 26 common miRNA gene targets. (e) 3′UTR of SV2B and miR-34a binding at site position 3909–3932, ΔGhybrid = − 27.500 kcal/mol. (f) 3′UTR of SV2B and miR-128-3p binding at site position 8986–8999, ΔGhybrid = − 17.900 kcal/mol. (g) 3′UTR of SV2B and miR-128-3p binding at site position 9532–9552, ΔGhybrid = − 19.300 kcal/mol. (h) 3′UTR of SV2B and miR-128-3p binding at site position 5671–5685, ΔGhybrid = − 17.600 kcal/mol.