Figure 3

SV2B string interaction network. (a) String interaction analysis of SV2B depicted that synaptotagmin 1 (SYT1) was directly co-expressed alongside SV2B (score 0.128). (b,c) GeneMANIA interactive network also illustrated strong co-expression between SV2B and SYT1, C6orf15, SCTR, SV2C, and SLC17A7. (d) HRNBP3, SULT4A1, SLC12A5, PACSIN1, GRIN1, VSNL1, PHYHIP, SYN2, CAMK2A, GLS2, NCDN, NRGN, SYT1, AK5, and NAPB positively co-expressed with SV2B. (e) Survival analysis depicted that higher levels of SV2B were associated with significantly shorter overall survival (p < 0.01119). (f) Disease specific survival analysis indicated that high SV2B expression was associated with shorter disease specific survival (p < 0.02197). (g) Progression free survival GBM analysis did not depict statistically significant differences.