Table 2 Effect of fluralaner on survivorship of Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus.
Dose | Median survival duration (in hours) | Cox-regression analysis | |
|---|---|---|---|
HR (95% CI) | P-value | ||
Aedes aegypti | |||
0 (Control) | – | 1.00 | – |
5 ng/mL | – | 3.45 (2.07–5.74) | < 0.001 |
10 ng/mL | 96 | 17.19 (10.86–27.22) | < 0.001 |
20 ng/mL | 48 | 40.61 (25.77–64.01) | < 0.001 |
35 ng/mL | 24 | 150.45 (94.76–238.87) | < 0.001 |
Anopheles stephensi | |||
0 (Control) | – | 1.00 | – |
5 ng/mL | – | 3.48 (2.02–5.97) | < 0.001 |
15 ng/mL | – | 17.21 (10.63–27.88) | < 0.001 |
25 ng/mL | 72 | 39.72 (24.73–63.80) | < 0.001 |
40 ng/mL | 24 | 231.94 (142.68–377.05) | < 0.001 |
Culex quinquefasciatus | |||
0 (Control) | – | 1.00 | – |
15 ng/mL | – | 3.72 (1.99–7.00) | < 0.001 |
30 ng/mL | – | 20.82 (11.88–36.49) | < 0.001 |
45 ng/mL | 48 | 91.53 (52.45–159.75) | < 0.001 |
60 ng/mL | 18 | 516.41 (292.07–913.07) | < 0.001 |
