Figure 2
From: Topical netarsudil for the treatment of primary corneal endothelial degeneration in dogs
Adverse events observed in a 10-year-old female Jack Russell terrier (A–D) and a 12-year-old Chihuahua mix (E, F) receiving topical netarsudil twice daily. Mild increase in conjunctival hyperemia developed after 4 months of topical netarsudil application (B) in comparison to before starting topical netarsudil (A). With slit lamp (C) and FD-OCT (D), intraepithelial bullae were observed 1 month after starting topical netarsudil (arrows). Focal corneal stromal hemorrhage associated with corneal vascularization was identified at 8 months (E). This dog had received topical netarsudil twice daily for the entire study period. The hemorrhage resolved 1 month after discontinuation of topical netarsudil and 4 months later, subepithelial melanin was observed in the superotemporal paraxial cornea (F).
