Figure 8

Kaplan Meier curves comparing clinical progression using the combined clinical criteria (A) and only corneal edema progression (B) in patients treated with ripasudil and netarsudil for 6 months. When looking at combined criteria, patients receiving ripasudil for 6 months were significantly less likely to progress compared with patients receiving netarsudil for 6 months (P = 0.04). However, no significant difference was observed when evaluating corneal edema only (P = 0.37). For these comparisons, data from 17 eyes from 11 dogs in treatment with ripasudil and 11 eyes from 9 dogs in treatment with netarsudil for 6-months were included. For the Kaplan Meier curves, progression was established using combined clinical criteria (A, progressed if eyes demonstrated a > 10% decrease in ECD, a > 10% increase of cornea affected by edema, and/or a > 20% increase in CCT) and corneal edema progression alone (B, when the eye had an increase of > 10% in area of the cornea affected by edema).