Table 16 The kinetics of release of isosorbide dinitrate from PLLA nanoparticles.

Formula No.		Zero-order		First order		Higuchi model		Korsmeyer-Peppas		Hixon-Crowell
Formula No.	pH	K₀	R²	K₁	R²	K_H	R²	K	R²	K	R²
F1	7.4	0.0344	0.970	0.204	0.905	0.013	0.613	0.0208	0.924	0.021	0.441
F1	6.7	0.001	0.956	0.008	0.836	0.013	0.873	0.016	0.973	0.047	0.516
F1	4.5	0.0009	0.966	0.004	0.8144	0.005	0.938	0.0199	0.970	0.009	0.776
F1	1.2	0.0001	0.631	0.001	0.494	0.003	0.834	0.013	0.943	0.005	0.897
F2	7.4	0.002	0.839	0.01	0.615	0.083	0.729	0.019	0.914	0.023	0.609
F2	6.7	0.018	0.988	0.087	0.957	0.080	0.934	0.022	0.930	0.028	0.524
F2	4.5	0.066	0.631	0.295	0.964	0.148	0.945	0.044	0.978	0.156	0.402
F2	1.2	0.016	0.965	0.069	0.751	0.066	0.976	0.023	0.983	0.040	0.557
F5	7.4	0.014	0.773	0.001	0.667	0.001	0.847	0.012	0.913	0.009	0.508
F5	6.7	0.0001	0.742	0.002	0.621	0.0019	0.850	0.026	0.924	0.011	0.526
F5	4.5	0.011	0.841	0.001	0.680	0.001	0.839	0.021	0.906	0.012	0.369
F5	1.2	0.017	0.815	0.001	0.755	0.001	0.833	0.010	0.930	0.013	0.300
F7	7.4	0.0007	0.427	0.0017	0.311	0.001	0.558	0.027	0.815	0.004	0.804
F7	6.7	0.0008	0.874	0.003	0.750	0.010	0.920	0.021	0.955	0.018	0.758
F7	4.5	0.0008	0.864	0.0029	0.704	0.009	0.881	0.018	0.938	0.027	0.494
F7	1.2	0.0004	0.708	0.0026	0.508	0.0012	0.783	0.026	0.894	0.007	0.777
F8	7.4	0.0005	0.921	0.0021	0.914	0.0008	0.841	0.017	0.916	0.010	0.409
F8	6.7	0.0001	0.518	0.0021	0.389	0.0019	0.643	0.018	0.850	0.005	0.918
F8	4.5	0.0002	0.755	0.0027	0.664	0.002	0.861	0.010	0.966	0.007	0.844
F8	1.2	0.005	0.9229	0.0002	0.797	0.0012	0.958	0.018	0.968	0.013	0.559
F9	7.4	0.0001	0.836	0.001	0.611	0.0019	0.917	0.017	0.938	0.006	0.794
F9	6.7	0.0009	0.993	0.002	0.953	0.014	0.955	0.0203	0.945	0.027	0.518
F9	4.5	0.025	0.644	0.001	0.483	0.0012	0.7403	0.020	0.889	0.009	0.687
F9	1.2	0.0002	0.898	0.0018	0.663	0.003	0.917	0.020	0.918	0.010	0.664

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