Figure 6

Prediction models of adverse cardiovascular events including platelet lipidomics risk scores outperformed conventional risk parameters. (A) Patients with CAD were partitioned into deciles according to predictive LASSO models and for each decile the fractional incidence of future CV events during the three-year follow-up is shown. The risk scores were calculated according to the included predictor variables: age/gender, CV risk factors (LVEF, LDL, HDL, triglycerides, HbA1c, platelet aggregation), platelet lipidome (mean concentrations of lysophosphatidylethanolamines (LPE) and acylcarnitines (CAR), and individual lipid LPE and CAR concentrations. The estimated mean incidence rate across the full cohort is indicated by the dotted line. (B) Predictive modeling of major bleeding events in patients with CAD employing different LASSO risk scores. Likewise, platelet lipids (LPE and CAR) were compared to baseline risk models (age/gender, CV risk factors) to assess the future case rates of incident bleeding.