Table 3 Cluster characteristics of the CAD patient cohort.
Cluster 1 (n = 155) | Cluster 2 (n = 111) | Cluster 3 (n = 158) | Cluster 4 (n = 89) | Cluster 5 (n = 58) | Cluster 6 (n = 24) | p-Value | |
|---|---|---|---|---|---|---|---|
Female, n (%) | 55 (35.5) | 28 (25.2) | 40 (25.2) | 26 (29.2) | 15 (25.9) | 10 (41.7) | 0.215 |
Age, years (mean ± SD) | 69 (± 12.3) | 71.8 (± 12.3) | 71.4 (± 10.3) | 64.7 (± 11.2) | 72.7 (± 10.5) | 73.4 (± 11) | 6.9*10−6 |
Body mass index (mean ± SD) | 26.4 (± 5.4) | 27 (± 5.1) | 27.3 (± 4.7) | 30.3 (± 5) | 27.7 (± 4.4) | 25.9 (± 3.3) | 6.3*10−7 |
Disease | |||||||
Chronic coronary syndrome, n (%) | 48 (31) | 34 (30.6) | 80 (50.6) | 25 (28.1) | 30 (51.7) | 10 (41.7) | 0.001 |
Unstable angina, n (%) | 22 (14.2) | 10 (9) | 25 (15.8) | 22 (24.7) | 8 (13.8) | 0 (0) | 0.013 |
NSTEMI, n (%) | 64 (41.3) | 50 (45.1) | 44 (27.9) | 27 (30.3) | 16 (27.6) | 9 (37.5) | 0.020 |
STEMI, n (%) | 21 (13.6) | 17 (15.3) | 9 (5.7) | 15 (16.9) | 4 (6.9) | 5 (20.8) | 0.026 |
Cardiovascular risk factors | |||||||
Arterial hypertension, n (%) | 133 (85.8) | 98 (88.3) | 145 (91.2) | 84 (94.4) | 51 (87.5) | 21 (89.4) | 0.331 |
Hyperlipidemia, n (%) | 132 (85.2) | 86 (77.5) | 117 (74) | 75 (84.3) | 42 (72.4) | 21 (87.5) | 0.070 |
Diabetes mellitus, n (%) | 22 (14.2) | 45 (40.54) | 43 (27.2) | 51 (57.3) | 28 (48.3) | 4 (16.67) | 2.5*10−12 |
Current smoking, n (%) | 31 (20.1) | 21 (18.9) | 24 (15.3) | 26 (29.2) | 6 (10.3) | 5 (20.8) | 0.064 |
Ex Smoking > 6 mo, n (%) | 32 (20.8) | 31 (27.9) | 28 (17.8) | 19 (21.4) | 16 (27.6) | 3 (12.5) | 0.272 |
Obesity, n (%) | 24 (15.5) | 19 (17.1) | 35 (22.2) | 46 (51.7) | 13 (22.4) | 2 (8.3) | 9.3*10−6 |
Atrial fibrillation, n (%) | 28 (18.2) | 34 (30.6) | 31 (19.8) | 12 (13.5) | 26 (44.8) | 8 (33.3) | 4.0*10−5 |
Previous CABG, n (%) | 1 (0.6) | 7 (6.3) | 5 (3.2) | 5 (5.6) | 3 (5.2) | 1 (4.2) | 0.180 |
Previous MI, n (%) | 13 (8.4) | 44 (39.6) | 34 (21.5) | 25 (28.1) | 12 (20.7) | 3 (12.5) | 1.4*10−7 |
Laboratory parameters | |||||||
LDL-cholesterol (mg/dL) (mean ± SD) | 153.5 (± 31.3) | 96.1 (± 39.7) | 77 (± 19.1) | 115 (± 38.2) | 78.8 (± 26.4) | 105.3 | 2.5*10−80 |
HDL-cholesterol (mg/dL) (mean ± SD) | 53.1 (± 17.8) | 44.3 (± 16) | 45.4 (± 15.2) | 34.8 (± 7.4) | 40.9 (± 12.8) | 53.1 (± 17.6) | 9.9*10−18 |
Triglycerides (mg/dL) (mean ± SD) | 124.1 (± 52.4) | 115.2 (± 51.6) | 108 (± 38.7) | 278.6 (± 121) | 123.5 (± 53.8) | 120.6 (± 69.5) | 1.44*10−70 |
Total cholesterol (mg/mL) (mean ± SD) | 210.1 (± 34.1) | 151.5 (± 41.8) | 136 (± 23.6) | 178.6 (± 37.8) | 134.3 (± 31.5) | 170.1 (± 44.4) | 6.2*10−72 |
HbA1c (%) (mean ± SD) | 5.9 (± 0.7) | 6.5 (± 1.3) | 6.1 (± 0.8) | 7 (± 1.5) | 6.5 (± 1.1) | 6 (± 0.5) | 4.1*10−15 |
Renal function (GFR) (mean ± SD) | 83.3 (± 22.1) | 72.6 (± 27.8) | 80.5 (± 35.9) | 82.5 (± 26.8) | 80.9 (± 29.6) | 83.5 (± 18.9) | 0.0663 |
LVEF (%) (mean ± SD) | 57 (± 5.2) | 37 (± 6.3) | 58.2 (± 4) | 57.2 (± 5.4) | 56.7 (± 6) | 52.8 (± 8.7) | 3.6*10−145 |
Platelets (109/l) (mean ± SD) | 235.4 (± 53.3) | 230.6 (± 76.8) | 211.2 (± 64.3) | 235.3 (± 68.4) | 226.7 (± 64.2) | 245.4 (± 74.4) | 0.010 |
Platelet Aggregation (AUC) (mean ± SD) | 22.5 (± 10.6) | 21.2 (± 11) | 19 (± 6.8) | 23.3 (± 9.6) | 45.3 (± 18.3) | 16.4 (± 8.7) | 6.3*10−49 |
Platelet lipidomics | |||||||
LPE (pmol/109 platelets) (mean ± SD) | 43.5 (± 54) | 41.1 (± 43.9) | 41.3 (± 61.1) | 37.5 (± 42) | 38.3 (± 56.2) | 1988.1 (± 303.3) | 9.8*10−11 |
CAR (pmol/109 platelets) (mean ± SD) | 6.7 (± 2.9) | 8.7 (± 4.1) | 5.8 (± 2.5) | 7 (± 3) | 11 (± 5.6) | 3.7 (± 1.5) | 7.2*10−27 |
