Table 2 Graft-versus-host disease (GVHD) occurrence before and after Clostridioides difficile infection.

From: Effective treatment of Clostridioides difficile infection improves survival and affects graft-versus-host disease: a multicenter study by the Polish Adult Leukemia Group

 

All patients n = 106*

GVHD prior to CDI diagnosis

GVHD after CDI diagnosis and treatment

P values

aGVHD

Group n = 94**

24 (25.5%)

39 (41.5%)

—Chronic: 5 (5.3%)

P = 0.005

aGVHD grade II-IV

 

13 (13.8%)

36 (33%)

P < 0.001

acute GI-GVHD

 

15 (15.9%)

29 (30.9%)

—Chronic-GI 2 (2.1%)

P = 0.016

Skin

 

13

  

Liver

 

5

  

cGVHD

Group n = 12***

cGVHD 5 (41.7%) only aGVHD history 4 (33.3%)

5 (41.7%)

P = NS

cGVHD moderate or severe

 

5 (41.7%)

5 (41.7%)

P = NS

GI-GVHD

 

3 (25%)

4 (33.3%)

P = NS

Skin

 

2

  

Liver

 

2

  

Other (eyes and mouth)

 

1

  
  1. aGVHD, Acute graft-versus-host disease; cGVHD, Chronic GVHD; GI-GVHD, Gastrointestinal GVHD.
  2. *3Patients with early death not related to CDI or GVHD with active CDI were excluded from post-CDI GVHD assessment.
  3. **Patients with CDI diagnosis peritransplant and in the early posttransplant period without cGVHD diagnosis prior to CDI.
  4. ***Patients with CDI diagnosed after Day + 100 (median Day + 231; range 103–740).
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