Table 1 Study cohort statistics and clinical features summary in CN and MCI/AD groups.

From: Predicting early Alzheimer’s with blood biomarkers and clinical features

 

CN

AD/MCI

P-value

Number of patients (total = 623)

212

411

 

Age

74.62 ± 5.44

72.69 ± 7.57

0.001

Gender (male)

107 (50.5)

251 (60.8)

0.017

APOE4 allele

58

231

< 0.001

Years of education

16.23 ± 2.67

15.97 ± 2.79

0.258

FDG

1.30 ± 0.11

1.22 ± 0.16

< 0.001

AV45

1.10 ± 0.18

1.22 ± 0.24

< 0.001

ABETA

1241.52 ± 429.99

1017.68 ± 450.14

< 0.001

TAU

247.91 ± 81.60

283.65 ± 131.37

0.005

PTAU

22.60 ± 8.35

27.04 ± 14.47

0.001

CDRSB

0.07 ± 0.30

2.50 ± 2.53

< 0.001

ADAS11

5.82 ± 2.84

12.03 ± 8.13

< 0.001

ADAS13

9.33 ± 4.32

18.63 ± 11.21

< 0.001

ADASQ4

2.94 ± 1.67

5.63 ± 2.88

< 0.001

MMSE

29.06 ± 1.24

26.41 ± 4.02

< 0.001

RAVLT_immediate

45.34 ± 10.55

33.46 ± 12.41

< 0.001

RAVLT_learning

5.72 ± 2.32

4.13 ± 2.76

< 0.001

RAVLT_forgetting

4.00 ± 2.85

4.46 ± 2.57

0.043

RAVLT_perc_forgetting

37.46 ± 27.34

61.10 ± 40.21

< 0.001

LDELTOTAL

14.11 ± 3.46

6.48 ± 4.38

< 0.001

TRABSCOR

82.18 ± 37.88

124.56 ± 72.44

< 0.001

FAQ

0.24 ± 1.07

6.05 ± 7.88

< 0.001

MOCA

25.46 ± 2.45

21.85 ± 4.73

< 0.001

EcogPtMem

1.54 ± 0.44

2.27 ± 0.71

< 0.001

EcogPtLang

1.38 ± 0.38

1.83 ± 0.63

< 0.001

EcogPtVisspat

1.13 ± 0.23

1.45 ± 0.58

< 0.001

EcogPtPlan

1.14 ± 0.25

1.52 ± 0.60

< 0.001

EcogPtOrgan

1.29 ± 0.40

1.67 ± 0.72

< 0.001

EcogPtDivatt

1.45 ± 0.51

1.92 ± 0.78

< 0.001

EcogPtTotal

1.33 ± 0.30

1.80 ± 0.56

< 0.001

EcogSPMem

1.27 ± 0.35

2.46 ± 0.94

< 0.001

EcogSPLang

1.13 ± 0.22

1.92 ± 0.83

< 0.001

EcogSPVisspat

1.07 ± 0.19

1.71 ± 0.83

< 0.001

EcogSPPlan

1.13 ± 0.23

1.90 ± 0.92

< 0.001

EcogSPOrgan

1.14 ± 0.36

2.01 ± 1.00

< 0.001

EcogSPDivatt

1.22 ± 0.39

2.23 ± 0.98

< 0.001

EcogSPTotal

1.16 ± 0.22

2.04 ± 0.82

< 0.001

Ventricles

34,517.16 ± 18,550.93

41,918.44 ± 24,315.44

< 0.001

Hippocampus

7270.30 ± 956.41

6743.25 ± 1263.40

< 0.001

WholeBrain

1,018,671.18 ± 107,104.07

1,033,167.05 ± 117693.19

0.141

Entorhinal

3754.57 ± 666.69

3491.00 ± 825.96

< 0.001

Fusiform

18,144.35 ± 2461.02

17,795.75 ± 2981.73

0.218

MidTemp

19,974.68 ± 2681.84

19,767.19 ± 3232.69

0.499

ICV

1,500,236.24 ± 156,407.97

1,533,944.09 ± 159,949.57

0.015

mPACCdigit

0.12 ± 2.94

− 8.16 ± 7.87

< 0.001

mPACCtrailsB

0.05 ± 2.66

− 7.22 ± 7.21

< 0.001

  1. Continuous variables are expressed as mean ± standard deviation.
  2. CN: cognitively norma; AD: Alzheimer’s disease; MCI: mild cognitive impairment. More details about the clinical features can be found in the “Alzheimer’s Disease Neuroimaging Initiative” section under “Methods”.
Back to article page