Table 2 Performance comparison with previously published methods.

From: Predicting early Alzheimer’s with blood biomarkers and clinical features

Model

Classification

Inputs

Accuracy

AUC

Reference

Random Forest with Chi-Square feature selection

Binary (CN, MCI/AD)

Gene expression and clinical data (no CS)

0.65

0.65

This work

AdaBoost model with no feature selection

Binary (CN, MCI/AD)

SNPs and clinical data (no CS)

0.67

0.63

This work

SVM model with MI feature selection

Binary (CN, MCI/AD)

SNPs and gene and clinical (with CS)

0.95

0.94

This work

Deep neural network (DNN)

Binary (CN, AD)

Blood gene expression

NA

0.656

Lee and Lee22

SVM

Binary (CN, AD)

Blood gene expression

NA

0.620

Lee and Lee22

BSWiMS-LASSO-RPART ensemble

Binary (CN, AD)

SNPs

0.677

0.719

Oriol et al.25

Deep learning models (DL)

Binary (CN, MCI/AD)

SNPs

0.66

NA

Venugopalan et al.36

  1. Evaluation datasets were derived from ADNI by the respective authors.
  2. BSWiMS: bootstrap stage-wise model selection; LASSO: least absolute shrinkage and selection operator; RPART: recursive partitioning and regression trees.