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Figure 1

From: Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Figure 1

Phylogenetic analysis of putative Ciona orexin receptors based on amino acid sequences; for the species codes, see Supplementary Table S1, for the sequences used, see Supplementary Information 1, and for the alignments, see Supplementary Information 2–3. The CiOX gene encodes for two transcripts (X1 and X2), of which the X2 transcript isolated from C. intestinalis is used in this study. Trees were constructed based on either full sequences (left) or TMs only (right), with three different phylogenetic construction methods as indicated. Robustness was assessed with 500 × bootstrap method (values in % at the intersections of the branches). Green, vertebrate orexin receptors; turquoise, cephalochordate orexin receptors; pink, protostome ATRs; purple, echinoderms/hemichordates orexin receptors; and yellow tunicate orexin receptors. The tree is rooted (grey) with human sequences of NPFF1 (NPFFR), GAL2 (GALR2), QFR (QRFPR), and ETB (ENDRB) receptors.

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