Figure 8 | Scientific Reports

Figure 8

From: Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates

Figure 8

Comparison of the binding interactions of human and C. intestinalis orexin peptides. (a) Cryo-EM structure of human orexin-B (dark green) bound to hOX2 (light green) (PDB ID: 7L1U), (b) homology model of the putative binding mode of human orexin-A (dark green) to CiOX (bleak yellow), and (c) homology model of the putative binding mode of Ci-orexin-A (orange) to CiOX (bleak yellow). Binding site side chains conserved between hOX2 and CiOX are shown as uncoloured sticks. Residues not conserved are shown in light green (hOX2) and bleak yellow (CiOX). Residues conserved between human and C. intestinalis orexin peptides are shown as blue sticks.

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