Figure 2
From: Impact of enriched environment on motor performance and learning in mice
Enriched-housed mice have slower acquisition of eyeblink conditioned responses than standard-housed mice. (A) Group averaged eyeblink traces (blue: standard-housed mice, n = 12; orange: enriched-housed mice, n = 16) of four training sessions during the 250 ms ISI paradigm and four training sessions during the 500 ms ISI paradigm. (B) Normalized eyelid closure calculated over all trials (NECall_trials) for the first ten days of training with and ISI of 250 ms (left panel), and second ten days of training with an ISI of 500 ms. Standard-housed mice showed faster learning in the 250 ms ISI. (C) Normalized eyelid closure calculated over trials with a CR (NECCR_trials) for the first ten days of training with and ISI of 250 ms (left panel), and second ten days of training with an ISI of 500 ms. No group differences were found. (D) Percentage of conditioned responses for the first ten days of training with and ISI of 250 ms (left panel) and second ten days of training with an ISI of 500 ms. the 500 ms ISI (day 11–20). Standard-housed mice showed faster learning in the 250 ms ISI. Abbreviations: CR conditioned response, CS conditioned stimulus, US unconditioned stimulus. All error bars represent the 95% confidence interval. *Significance level p < 0.05 after correction Bonferroni-Holm.
