Table 3 Overview of the top 10 GO-MF terms.
From: Identification of key autophagy-related genes and pathways in spinal cord injury
Term | Count | % | P value | Genes |
|---|---|---|---|---|
GO:0005515 ~ protein binding | 83 | 64.34109 | 1.76E−17 | TOP2A, COL18A1, CDKN1A, MCM7, ITGB2, SERPINE1, TNFAIP3, TREM2, FOXM1, TNF, PIK3CG, PTBP1, LGALS3, CASP7, CASP8, LGALS1, CTSL, MYC, CASP4, ZC3H12A, CHEK1, TNFAIP8L1, CASP1, LGALS9, KPNA2, TNPO1, IKBKE, CTSD, ANXA1, ANXA2, RIPK3, HGF, NEAT1, RUNX2, TNFRSF1A, TGFBR2, RAB32, VAMP8, AR, BIRC5, MYH9, PLIN2, TRIB3, S100A4, ITGA5, NUPR1, PFN1, TLR4, CD44, EPHA2, BIRC3, TLR2, CEBPB, GRN, PCNA, CXCR4, NOD2, PTGS2, THBS1, AURKB, AURKA, PLAC8, EIF4EBP1, PMAIP1, FLNA, CCL2, RIPK1, XDH, TGFB1, MLKL, CDKN2A, BIK, PLK1, FN1, NR1H4, IGF1, IL6, CDK6, CDK1, FAS, P4HB, VIM, EZH2 |
GO:0042802 ~ identical protein binding | 43 | 33.33333 | 3.36E−12 | COL18A1, CEBPB, CD84, PCNA, HSPB1, TNFAIP3, BRCA1, ZC3HAV1, MEFV, TNF, PIK3CG, LMAN1, CASP8, LGALS1, CASP1, TNFAIP8L1, HMOX1, OLR1, RIPK1, FLNC, CCR5, XDH, IKBKE, TGM2, TGFB1, ANXA1, APAF1, MLKL, ANXA2, RIPK3, HGF, PLK1, FN1, TNFRSF10B, BST2, DAO, FAS, BIRC5, MYH9, S100A4, VIM, TLR4, TLR2 |
GO:0005178 ~ integrin binding | 11 | 8.527132 | 8.58E−08 | MMP14, IL1B, ITGB2, FN1, SPP1, MYH9, ITGAV, IGF1, ITGA5, P4HB, THBS1 |
GO:0002020 ~ protease binding | 10 | 7.751938 | 1.53E−06 | CSTB, ANXA2, SERPINE1, FN1, FAS, TNFAIP3, TNFRSF10B, ITGAV, TNF, TNFRSF1A |
GO:0019899 ~ enzyme binding | 13 | 10.07752 | 7.61E−05 | TOP2A, PCNA, TGFB1, FN1, NOD2, BRCA1, PTGS2, AR, HMOX1, BIRC5, TRIB3, P4HB, LGALS9 |
GO:0001968 ~ fibronectin binding | 5 | 3.875969 | 9.81E−05 | CTSL, IGFBP3, ITGAV, THBS1, CTSS |
GO:0019901 ~ protein kinase binding | 14 | 10.85271 | 1.28E−04 | CDKN1A, MLKL, CDKN2A, PLK1, ITGB2, HSPB1, NOD2, FOXM1, AURKA, MYH9, TRIB3, VIM, CCR5, CD44 |
GO:0016301 ~ kinase activity | 15 | 11.62791 | 1.51E−04 | RIPK3, SPHK1, PLK1, PIK3CG, AURKB, HK2, AURKA, TGFBR2, NUAK2, CDK6, CHEK1, CDK1, RIPK1, IKBKE, EPHA2 |
GO:0004674 ~ protein serine/threonine kinase activity | 12 | 9.302326 | 1.59E−04 | NUAK2, CDK6, RIPK3, PLK1, CHEK1, CDK1, RIPK1, IKBKE, PIK3CG, AURKB, TGFBR2, AURKA |
GO:0000166 ~ nucleotide binding | 26 | 20.15504 | 1.80E−04 | TOP2A, MCM7, NOD2, AURKB, PIK3CG, HK2, AURKA, TUBA1C, TUBB6, NUAK2, CHEK1, RIPK1, IKBKE, TGM2, APAF1, MLKL, RIPK3, SPHK1, PLK1, TGFBR2, RAB32, CDK6, CDK1, MYH9, EPHA2, TUBA8 |
