Figure 2

Glucose-stimulated insulin and glucagon secretions of porcine islet organoids on day 11. (A) and (B) Glucose-stimulated insulin secretion (A) and insulin content (B) in overnight-cultured islets (Day 1, blue), 11 day-cultured islets (Day 11, orange), and islet organoids (Organoid day 11, gray). (C) and (D) Glucose-stimulated glucagon secretion (C) and glucagon content (D) in 11 days cultured islets (Day 11, orange) and islet organoid (Organoid day 11, gray). n = 3. Data are means ± standard error of the median (SEM). *p < 0.05, **p < 0.01, ***p < 0.001.