Table 3 Comparisons of optical coherence tomography angiography measures in eyes of optic nerve hypoplasia patients and controls.

From: Optical coherence tomography and optical coherence tomography angiography findings in optic nerve hypoplasia and their relationships with visual acuity

 

ONH patients

(n = 17)

Controls

(n = 34)

Univariable analysis

Multivariable analysisb

Estimate

95% CI

p valuea

Estimate

95% CI

p valuea

SRCP, % area

 Average

50.03 ± 4.23

48.64 ± 1.86

1.386

−0.751, 3.523

0.3055

1.278

−0.753, 3.310

0.2175

 Superior

49.58 ± 5.75

49.52 ± 2.20

0.052

−2.832, 2.936

0.9716

0.455

−2.172, 3.081

0.7342

 Temporal

51.46 ± 5.83

48.30 ± 2.77

3.163

0.158, 6.168

0.1066

2.874

0.465, 5.283

0.0581

 Inferior

48.18 ± 5.65

49.07 ± 3.68

−0.893

−3.936, 2.150

0.6783

−0.982

−4.311, 2.347

0.6759

 Nasal

50.90 ± 6.61

47.67 ± 2.67

3.222

−0.046, 6.490

0.1066

2.766

0.006, 5.527

0.0990

DRCP, % area

 Average

53.55 ± 4.12

50.80 ± 2.78

2.749

0.361, 5.136

0.0481

2.693

0.704, 4.682

0.0120

 Superior

53.20 ± 4.52

52.69 ± 4.80

0.518

−2.057, 3.094

0.6931

0.538

−2.155, 3.231

0.6955

 Temporal

53.25 ± 6.68

49.48 ± 4.89

3.774

0.151, 7.398

0.0618

3.770

1.184, 6.357

0.0086

 Inferior

53.57 ± 5.25

51.96 ± 5.14

1.601

−1.810, 5.011

0.4291

1.529

−2.022, 5.081

0.4784

 Nasal

54.17 ± 6.58

49.07 ± 3.46

5.102

1.467, 8.736

0.0178

4.934

1.898, 7.970

0.0043

RPC, % area

 Average

56.20 ± 8.02

60.38 ± 2.89

−4.178

−8.159, −0.197

0.0793

−4.576

−8.819, −0.332

0.0691

 Superior

64.26 ± 11.31

69.40 ± 4.88

−5.147

−10.584, 0.291

0.0953

−5.697

−11.752, 0.359

0.0978

 Temporal

52.40 ± 13.73

51.34 ± 5.27

1.064

−6.572, 8.699

0.7849

1.288

−5.674, 8.250

0.7169

 Inferior

61.14 ± 13.13

70.17 ± 5.36

−9.033

−15.549, −2.517

0.0198

−10.848

−15.775, −5.921

0.0001

 Nasal

47.01 ± 13.10

50.60 ± 5.18

−3.597

−11.015, 3.821

0.4103

−3.045

−11.810, 5.719

0.5950

  1. ONH optic nerve hypoplasia; n numbers; SRCP superficial retinal capillary plexus; DRCP deep retinal capillary plexus; RPC radial peripapillary capillary; CI confidence interval.
  2. Values are shown as mean ± standard deviation.
  3. Estimate and 95% CI were calculated by Generalized Estimating Equation (GEE).
  4. aP value was calculated by Benjamini–Hochberg correction for multiple outcomes.
  5. bMultivariable analysis with adjustment for age and spherical equivalent refractive errors.
  6. Bold value indicates p < 0.05.
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