Figure 4
From: Single nuclei transcriptomics of the in situ human limbal stem cell niche
Expression profiles of putative LSC markers in the limbus. (A) Localization and (B) expression levels of AC093496.1, NOTCH1, GPHA2, MMP10, BMI1, CASP14, ABCB5, and ABCG2. We found that AC093496.1 and MMP10 expression was largely specific to the TACs sub-population and may represent the best markers for corneal epithelial cell progenitors. GPHA2 was expressed in a sub-set of TACs and differentiated corneal epithelial cells. A small proportion of the LSC cluster showed NOTCH1 expression, which was widely expressed in other epithelial cell types, much and like BMI1 and CASP14. We did not observe high expression of either of the ATP transporters, ABCB5 or ABCG2, in the LSC or TAC progenitor populations. In fact, ABCB5 expression was confined to the melanocyte population in our dataset.
