Figure 6
From: Single nuclei transcriptomics of the in situ human limbal stem cell niche
Pseudo-time analysis of LSC differentiation to corneal epithelial cells. LSCs (purple) and TACs (cyan) exhibit a similar gene expression pattern and overlap in a trajectory analysis of LSC differentiation, suggesting that LSCs are uni-potent progenitors of TACs. Differentiated corneal epithelial cells (orange) are defined by increased KRT12 expression and a loss of S100A2. Overall, LSC differentiation is defined by a loss of stem cell quiescence, centripetal migration towards the central cornea and a subsequent increase in KRT12 expression and loss of S100A2 expression.
