Figure 7
From: Single nuclei transcriptomics of the in situ human limbal stem cell niche
Schematic of LSC renewal of the corneal epithelium. (A) Quiescent LSCs (black) at the limbus and corneal periphery are uni-potent progenitors of the corneal epithelium that can self-renew to maintain a stem cell population. They give rise to the corneal epithelial cells in the centre in a centripetal fashion, as has been shown in lineage tracing and label-retention studies. (B) LSCs self-renew and give rise to transiently amplifying progenitor cells, which express the markers MMP10, AC093496.1, S100A2, and SLC6A6. As basal corneal epithelial cells become supra-basal cells, they express KRT24 before terminally differentiating and expressing KRT12 and KRT3.
