Table 2 Body composition, muscle strength, physical function, and prevalence of sarcopenia in the three FIB-4 index groups.

From: Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease

 

All subjects (n = 117)

Low FIB-4 index (n = 36)

Intermediate FIB-4 index (n = 18)

High FIB-4 index (n = 63)

p value

ASM (kg)

17.79 (14.54–20.67)

18.49 (15.95–21.13)

15.59 (13.75–19.33)

17.79 (14.52–20.87)

0.252

SMI (kg/m2)

6.83 (6.32–7.48)

7.04 (6.52–7.48)

6.59 (5.95–7.51)

6.71 (6.17–7.47)

0.361

Male < 7.0, Female < 5.4 (yes/no)

35 (30)/82 (70)

11 (31)/25 (69)

3 (17)/15 (83)

21 (33)/42 (67)

0.417

ECW/TBW

0.391 (0.385–0.396)

0.389 (0.383–0.395)

0.391 (0.385–0.398)

0.392 (0.387–0.397)

0.234

KEF (kgf)

32.1 (25.3–39.5)

36.5 (27.0–41.4)

31.9 (25.2–44.6)

30.5 (24.7–.35.8)

0.276

KEF/weight (kgf/kg)

0.54 (0.43–0.62)

0.55 (0.44–0.63)

0.48 (0.43–0.64)

0.54 (0.41–0.60)

0.774

Grip strength (kg)

24.8 (19.5–32.1)

25.6 (20.8–34.2)

22.6 (19.4–32.5)

24.3 (18.5–30.8)

0.351

Male < 28, Female < 18 (yes/no)

41 (35)/76 (65)

11 (31)/25 (69)

4 (22)/14 (78)

26 (41)/37 (59)

0.296

Gait speed (m/s)

1.10 (0.90–1.24)

1.15 (1.08–1.28)

1.10 (0.98–1.19)

1.05 (0.86–1.24)

0.134

 < 1.0 m/s (yes/no)

36 (31)/81 (69)

6 (17)/30 (83)

4 (22)/14 (78)

26 (41)/37 (59)

0.029*

0.4–0.6 m/s (%)

n = 1

2.78

0

0

 

0.6–0.8 m/s (%)

n = 14

5.56

5.56

17.46

 

0.8–1.0 m/s (%)

n = 21

8.33

16.67

23.81

 

1.0–1.2 m/s (%)

n = 49

52.78

55.56

31.75

 

1.2–1.4 m/s (%)

n = 20

16.67

16.67

17.46

 

1.4–1.6 m/s (%)

n = 10

11.11

5.56

7.94

 

1.6–1.8 m/s (%)

n = 2

2.78

0

1.59

 

Sarcopenia AWGS2019(yes/no)

20 (17)/97 (83)

7 (19)/29 (81)

2 (11)/16 (89)

11 (17)/52 (83)

0.796

Sarcopenia JSH2nd (yes/no)

18 (15)/99 (85)

6 (17)/30 (83)

2 (11)/16 (89)

10 (16)/53 (84)

0.941

  1. Continuous variables are presented as median (interquartile range). Categorical variables are presented as number (percentage).
  2. FIB-4, Fibrosis 4; ASM, Appendicular skeletal muscle mass; SMI, Skeletal muscle mass index; ECW, Extracellular water; TBW, Total body water; ECW/TBW, Ratio of extracellular water to total body water; KEF, Knee extension force; AWGS, Asian Working Group for Sarcopenia; JSH, Japan Society of Hepatology.
  3. *p < 0.05.