Table 3 Regions with decreased grey matter volume associated with increasing age in smokers and healthy non-smokers.
Group | Region | Size | MNI coordinates (x, y, z) | Size p-FWE | Z-score |
|---|---|---|---|---|---|
Smokers | R superior temporal sulcus | 744 | 46.5, − 33, 9 | < .001 | 6.23473 |
L superior frontal gyrus | 170 | − 22.5, 9, 49.5 | < .001 | 5.52216 | |
L pars orbitalis | 205 | − 48, 52.5, − 9 | < .001 | 5.46216 | |
R rostral middle frontal gyrus | 48 | 42, 36, − 13.5 | < .01 | 5.39401 | |
R parahippocampal gyrus | 58 | 18, − 36, − 9 | < .01 | 5.20859 | |
R frontal pole | 22 | 10.5, 66, − 7.5 | < .05 | 5.07721 | |
R middle temporal gyrus | 21 | 64.5, − 27, − 13.5 | < .05 | 5.07263 | |
L superior temporal gyrus | 12 | − 48, − 13.5, − 4.5 | < .05 | 5.06362 | |
L frontal operculum | 28 | − 43.5, 18, − 1.5 | < .01 | 5.02166 | |
L pars triangularis | 81 | − 43.5, 37.5, 16.5 | < .01 | 5.02065 | |
L middle frontal gyrus | 18 | − 51, 16.5, 31.5 | < .05 | 4.99003 | |
R pars orbitalis | 59 | 34.5, 61.5, 10.5 | < .01 | 4.96308 | |
R superior frontal gyrus | 21 | 10.5, 54, 30 | < .05 | 4.91427 | |
L rostral middle frontal gyrus | 10 | − 13.5, 61.5, 0 | < .05 | 4.91418 | |
L superior temporal gyrus | 10 | − 48, 4.5, − 3 | < .05 | 4.79388 | |
Non− smokers | Bilateral superior frontal gyri | 103 | 0, 37.5, 36 | < .001 | 5.317041 |
L superior temporal gyrus | 13 | − 39, 10.5, − 34.5 | < .05 | 4.970372 | |
L insula | 25 | − 30, 7.5, − 9 | < .05 | 4.913628 | |
L posterior cingulate gyrus | 18 | − 4.5, − 33, 48 | < .05 | 4.881205 | |
R putamen | 13 | 31.5, − 1.5, 1.5 | < .05 | 4.764697 |
