Figure 5 | Scientific Reports

Figure 5

From: RNA-binding proteins potentially regulate the alternative splicing of cell cycle-associated genes in proliferative diabetic retinopathy

Figure 5

Validation of DE RBPs and ASEs in the OIR mouse model. (A,D,F,H,J) RT-PCR analysis for DE RBPs (Hsp90aa1, Macf1, Sfpq, Map1b, and Tpt1) in the retinas of OIR mice at P17. (B) RT-PCR analysis for DE ASEs (CCNH) in the retinas of OIR mice at P17. (C,E,G,I) Bar diagram showing MACF1, SFPQ, MAP1B, and TPT1. *P < 0.05, ***P < 0.001. ASEs, alternative splicing events; CCNH, CyclinH; DE RBPs, differentially expressed RNA-binding proteins; OIR, oxygen-induced retinopathy; MACF1, microtubule-actin crosslinking factor 1; MAP1B, microtubule-actin crosslinking factor 1; SFPQ, splicing factor proline/glutamine rich; Tpt1, tumor protein translationally controlled 1.

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