Table 9 Toxicity Evaluation of the identified metabolites in Z. nummularia ethyl acetate and ethanol extracts using the Protox II Web Server.
Metabolite name | Organ toxicity (%Probability) | Toxicity endpoint (% Probability) | |||
|---|---|---|---|---|---|
Hepatotoxicity | Carcinogenicity | Immunotoxicity | Mutagenicity | Cytotoxicity | |
Guaifenesin | Inactive | Inactive | Inactive | Inactive | Inactive |
(0.99) | (0.81) | (0.86) | (0.73) | (0.90) | |
Quercetin | Inactive | Active | Inactive | Active | Inactive |
(0.69) | (0.68) | (0.87) | (0.51) | (0.99) | |
2-Methoxy-4-Vinylphenol | Inactive | Inactive | Active | Inactive | Inactive |
(0.66) | (0.61) | (0.59) | (0.97) | (0.88) | |
3-P-Coumaroylquinic Acid | Inactive | Inactive | Active | Inactive | Inactive |
(0.75) | (0.70) | (0.97) | (0.93) | (0.80) | |
Chlorogenic Acid | Inactive | Inactive | Active | Inactive | Inactive |
(0.72) | (0.68) | (0.99) | (0.93) | (0.80) | |
Lupeol | Inactive | Inactive | Active | Inactive | Inactive |
(0.91) | (0.63) | (0.57) | (0.95) | (0.97) | |
Rutin | Inactive | Inactive | Active | Inactive | Inactive |
(0.80) | (0.91) | (0.98) | (0.88) | (0.64) | |
Beta-Caryophyllene | Inactive | Inactive | Active | Inactive | Inactive |
(0.80) | (0.70) | (0.54) | (0.95) | (0.75) | |
Procyanidin B1 | Inactive | Inactive | Active | Inactive | Inactive |
(0.74) | (0.54) | (0.92) | (0.59) | (0.80) | |
Nummularine R | Inactive | Inactive | Active | Inactive | Inactive |
(0.61) | (0.55) | (0.99) | (0.66) | (0.52) | |
2-Isobutyl-3-Methoxypyrazine | Inactive | Inactive | Inactive | Inactive | Inactive |
(0.64) | (0.60) | (0.98) | (0.75) | (0.84) | |
Nummularine A | Inactive | Inactive | Inactive | Inactive | Inactive |
(0.63) | (0.61) | (0.73) | (0.64) | (0.54) | |
Luteolin-7-O-glucoside | Inactive | Inactive | Inactive | Inactive | Inactive |
(0.82) | (0.85) | (0.74) | (0.76) | (0.69) | |
