Figure 4 | Scientific Reports

Figure 4

From: White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma

Figure 4

Traumatic brain injury causes hippocampal and cortical damage. Time-dependent progression of histopathological changes after TBI and rmTBI. (A) H&E-stained brain sections showed cell shrinkage with dark-stained pyknotic nuclei and perineuronal vacuolization in the hippocampus, cortex, hypothalamus, and striatum. The boxed areas in the full-size brain image on the top left graphic are magnified in the representative image. Scale bar, 100 μm. Bar graph representing the mean ± SD (n = 10 of Sham, n = 4–8 of TBI, and n = 8–10 of rmTBI) of neuronal damage scores in (B) hippocampus-CA1 region, (C) hippocampus-CA2 region, (D) hippocampus-CA3 region, (E) hippocampus-DG region, (F) cortex, (G) hypothalamus, and (H) striatum at different time points after TBI for each experimental group of rats. *P < 0.05, compared with the sham group. +P < 0.05, compared with the TBI group.

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