Figure 7

TBI causes alterations in DTI parameters. Coronal images of the diffusion parameter map (bregma + 0.20 mm to − 5.3 mm) were obtained from a TBI and a rmTBI rat at month 9 (M9) post-injury. (A) Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) maps are shown, and the data are summarized in Table 1 and Supplementary file. The cFA brain map with direction-encoded color maps was based on the extracted direction: red was for medial–lateral (x-axis), green was for rostral-caudal (y-axis), and blue was for dorsal–ventral (z-axis). The grayscale indicates FA values between 0 (black) and 1 (white) and AD, RD, and MD values between 0 (black) and 255 (white). The four indices FA, AD, RD, and MD for each brain structure are analyzed at M9 of post-injury, including (B) CCb, (C) CCs, (D) ic, (E) ab, (F) cortex, (G) hippocampus, and (H) striatum. Blue bars represent the Sham group (n = 12), orange bars TBI group (n = 9), and purple bars rmTBI group (n = 8). *P < 0.05, compared with the sham group. The “Supplementary Data" file shows DTI brain maps at the other time points and the statistical analysis data.