Figure 8 | Scientific Reports

Figure 8

From: White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma

Figure 8

TBI causes brain cavity formation and white matter thickness reduction. Luxol fast blue (LFB) and cresyl violet (or Nissl) staining show the temporal progression of the brain lesion. LFB staining was used to identify myelin. Cresyl violet was used to stain neuronal cell bodies, processes, and Nissl bodies. (A) Representative LFB with Nissl staining from coronal sections at 9 months (M9) post sham operation, post TBI, and post rmTBI. For all time points in coronal sections from D3 to M9 of each group, please see Figure S7 in the “Supplementary Data” file. (B) Quantification of brain cavity volume (lesion volume) in different severities of TBI. Data are presented as mean ± SD (n = 12 of Sham, n = 9 of TBI, and n = 8 of rmTBI). *P < 0.05, compared with the sham group. +P < 0.05, compared with the TBI group.

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