Table 1 Fractional anisotropy (FA) and axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD) from ipsilateral and contralateral hemisphere in sham control (n = 6) and rats after mTBI (n = 6) or rTBI at month 9 (n = 6) obtained using in vivo DTI.

From: White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma

 

FA

AD

RD

MD

Sham

mTBI

rTBI

Sham

mTBI

rTBI

Sham

mTBI

rTBI

Sham

mTBI

rTBI

Ipsilateral

 WM:

  CCb

0.54 ± 0.01

0.43 ± 0.03*

0.39 ± 0.03*

1.28 ± 0.02

1.68 ± 0.20*

1.47 ± 0.11

0.57 ± 0.04

0.95 ± 0.12

1.13 ± 0.11*

0.85 ± 0.04

1.21 ± 0.12

1.39 ± 0.12*

  CCs

0.56 ± 0.02

0.33 ± 0.03*

0.33 ± 0.02*

1.21 ± 0.02

0.99 ± 0.03*

0.99 ± 0.02

0.45 ± 0.02

0.59 ± 0.02*

0.60 ± 0.02*

0.70 ± 0.01

0.72 ± 0.02*

0.73 ± 0.02*

  ic

0.60 ± 0.01

0.54 ± 0.01*

0.62 ± 0.02 + 

1.34 ± 0.03

1.30 ± 0.02

1.27 ± 0.01

0.46 ± 0.02

0.51 ± 0.01

0.41 ± 0.01 + 

0.75 ± 0.02

0.77 ± 0.01

0.70 ± 0.01

  ab

0.54 ± 0.02

0.46 ± 0.03

0.43 ± 0.02*

1.23 ± 0.03

1.16 ± 0.03

1.12 ± 0.03

0.47 ± 0.02

0.53 ± 0.04

0.54 ± 0.03

0.73 ± 0.02

0.74 ± 0.02

0.74 ± 0.02

 GM:

  Cortex

0.19 ± 0.01

0.20 ± 0.01

0.20 ± 0.01

0.82 ± 0.01

1.51 ± 0.20*

1.24 ± 0.24*

0.61 ± 0.01

1.16 ± 0.16*

1.19 ± 0.19*

0.69 ± 0.01

1.28 ± 0.17*

1.32 ± 0.20*

  Hippo

0.23 ± 0.01

0.19 ± 0.01*

0.19 ± 0.01*

0.94 ± 0.02

1.45 ± 0.02*

1.90 ± 0.13* + 

0.65 ± 0.01

1.10 ± 0.18*

1.45 ± 0.11* + 

0.74 ± 0.01

1.22 ± 0.19*

1.60 ± 0.11* + 

  Stria

0.24 ± 0.01

0.24 ± 0.01

0.24 ± 0.01

0.86 ± 0.01

0.97 ± 0.05*

0.95 ± 0.03

0.60 ± 0.01

0.68 ± 0.04*

0.68 ± 0.02*

0.69 ± 0.01

0.77 ± 0.04*

0.77 ± 0.02*

Contralateral

        

 WM:

  CCb

0.56 ± 0.01

0.38 ± 0.04*

0.36 ± 0.04*

1.31 ± 0.02

1.30 ± 0.04

1.31 ± 0.09

0.54 ± 0.03

1.26 ± 0.21*

1.33 ± 0.15*

0.83 ± 0.03

1.52 ± 0.20*

0.83 ± 0.03*

  CCs

0.54 ± 0.02

0.30 ± 0.05*

0.24 ± 0.02*

1.19 ± 0.02

1.55 ± 0.21

1.52 ± 0.14

0.47 ± 0.02

1.07 ± 0.21

1.11 ± 0.11

0.70 ± 0.01

1.23 ± 0.21

1.25 ± 0.12

  ic

065 ± 0.01

0.55 ± 0.02*

0.58 ± 0.03*

1.33 ± 0.04

1.20 ± 0.01*

1.34 ± 0.03 + 

0.40 ± 0.01

0.47 ± 0.03

0.49 ± 0.04*

0.71 ± 0.02

0.71 ± 0.02

0.78 ± 0.03

  ab

0.55 ± 0.01

0.32 ± 0.03*

0.29 ± 0.03*

1.23 ± 0.03

1.54 ± 0.21

1.77 ± 0.29*

0.47 ± 0.02

0.99 ± 0.19*

1.23 ± 0.26*

0.72 ± 0.02

1.17 ± 0.19*

1.41 ± 0.27*

 GM:

  Cortex

0.18 ± 0.01

0.18 ± 0.07

0.15 ± 0.01

0.85 ± 0.01

0.87 ± 0.02

0.83 ± 0.02

0.65 ± 0.01

0.66 ± 0.01

0.66 ± 0.02

0.71 ± 0.01

0.73 ± 0.02

0.72 ± 0.02

  Hippo

0.26 ± 0.01

0.25 ± 0.01

0.25 ± 0.01

1.00 ± 0.02

1.06 ± 0.03

1.16 ± 0.07

0.66 ± 0.01

0.71 ± 0.03

0.78 ± 0.05

0.77 ± 0.02

0.83 ± 0.03

0.91 ± 0.06

  Stria

0.23 ± 0.01

0.23 ± 0.01

0.24 ± 0.01

0.86 ± 0.01

0.85 ± 0.02

0.84 ± 0.01

0.61 ± 0.01

0.59 ± 0.02

0.58 ± 0.01

0.69 ± 0.01

0.68 ± 0.02

0.67 ± 0.01

  1. Statistical significance are *P < 0.05 comparing the same hemisphere in sham control and rats after TBI (one-way ANOVA with Tukey's multiple comparisons test) and + p < 0.05 comparing the same hemisphere in rTBI group and mTBI group. CCb, Body of the corpus callosum; CCs, Splenium of the corpus callosum; ic, Internal capsule; ab, Anterior commissure; Hippo, Hippocampus; Stria.: Striatum; WM, White matter; GM, Gray matter. Bold text for significantly increased values and significantly decreased values.
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