Figure 1

Unsupervised MVDA of VE6 exometabolomes: (a) PCA score plot, where each point confined in Hotelling’s T2 ellipsoids corresponds to NMR data from each cell supernatant replicate. The grouping association to treatments is outlined by a specific color code: VE6 (gray dots); VE6+ (red dots); VE6+RDV (green dots); VE6+AZI (cyan dots); VE6+R + A (blue dots). Percentages explained by the first (PC 1) and second (PC 2) components were also reported. (b) PCAToTree2 dendrogram corresponding to the computed PCA score plots using Mahalanobis distances, with p-values for the null hypothesis (p < 0.05) at each branch.