Table 1 Basic characteristics of included studies.

From: Morphology of the papilla can predict procedural safety and efficacy of ERCP—a systematic review and meta-analysis

Author

Year

Country

Centers

Study type

Study period

Age (*:mean; #:median)

Sex (female %)

Number of patients

Classification

Outcomes

Balan et al.15

2020

Romania

1

Prospective cohort

January 2018 to August 2018

NA

NA

322

Regular: 52%

Canard type I 11%:

Canard type II: 19%

Canard type III: 10%

Canard type IV: 8%

Difficult cannulation

Cannulation time

Cannulation attempts

Post-ERCP pancreatitis

Post-ERCP bleeding

Post-ERCP infection

Canena et al.16

2021

Portugal

3

Prospective cohort

May 2018 to October 2020

*69.6

56.8%

361

Viana type I: 13%

Viana type IIa: 35%

Viana type IIb: 30%

Viana type IIc:10%

Viana type IIIa: 4%

Viana type IIIb: 4%

Viana type IV: 4%

Cannulation failure

Cannulation time

Post-ERCP pancreatitis

Post-ERCP bleeding

Post-ERCP perforation

Chen et al.5

2020

Taiwan

1

Prospective cohort

October 2017 to October 2018

*64 (SD: 16.5)

47.5%

286

Haraldsson type I: 41%

Haraldsson type II: 9%

Haraldsson type III: 22%

Haraldsson type IV: 28%

Cannulation failure

Cannulation time

Post-ERCP pancreatitis

Post-ERCP bleeding

Post-ERCP perforation

Post-ERCP cholangitis

Fernandes et al.18

2018

Portugal

3

Prospective cohort

August 2017 to January 2018

#79

59.4%

106

Leés type I: 50%

Leés type II: 32%

Leés type III: 12%

Leés type IV: 6%

Cannulation time

Gutierrez- De Aranguren et al.19

2021

Peru

1

Retrospective cross-sectional

July 2019 to April 2021

*55 (SD:2 0)

66.5%

188

Haraldsson type I: 32%

Haraldsson type II: 25%

Haraldsson type III: 27%

Haraldsson type IV: 16%

Difficult cannulation

Haraldsson et al.4

2019

Nordic countries

9

Prospective cohort

NA

66 (SD: 16)

52%

1377

Haraldsson type I: 56%

Haraldsson type II: 13%

Haraldsson type III: 23%

Haraldsson type IV: 8%

Difficult cannulation

Cannulation time

Post-ERCP pancreatitis

Liu et al.20

2021

China

1

Retrospective cohort

January 2008 to December 2017

NA

NA

11 090

Normal: 44%

Thick and long: 11%:

Peridiverticular: 27%

Intradiverticular: 5%

Ectopic: 1%

Edematous 10%:

Ulcerative: 2%

Difficult cannulation

Mohamed et al.6

2021

Canada

1

Retrospective cohort

September 2018 to January 2020

NA

51.8%

637

Haraldsson type I: 62%

Haraldsson type II: 5%

Haraldsson type IIIa: 9%

Haraldsson type IIIb: 9%

Haraldsson type IV: 3%

Type D: 12%

Cannulation failure

Cannulation time

Cannulation attempts

Post-ERCP pancreatitis

Post-ERCP bleeding

Post-ERCP infection

Post-ERCP cholangitis or sepsis

Nakeeb et al.17

2016

Egypt

1

Prospective cohort

August 2012 to September 2014

*58.4 (SD: 14.7)

44.4%

996

Normal: 60%

Atrophic: 3%

Pregnant: 7%

Tumor: 7%

Redundant: 8%

Juxtadivertcular: 8%

Small: 6%

Long: 1%

Post-ERCP pancreattis

Onilla et al.21

2021

Philippines

1

Retrospective cohort

January 2017 to December 2019

NA

NA

347

Regular protrusion: 57%

Small protrusion: 31%

Large protrusion: 12%

Annular pattern: 72%

Unstructured pattern: 11%

Longitudinal pattern 11%: Isolated pattern: 1%

Gyrus pattern: 5%

Difficult cannulation

Cannulation failure

Quiroga-Purizaca et al.22

2022

Peru

1

Propective cohort

NA

*51.5 ( CI 48.8–54.1)

68.4%

138

Haraldsson type I: 59%

Haraldsson type II: 8%

Haraldsson type III: 29%

Haraldsson type IV: 4%

Difficult cannulation

Cannulation time

Cannulation attempts

Post-ERCP pancreatitis

Post-ERCP bleeding

Post-ERCP perforation

Sadeghi et al.23

2019

Iran

1

Prospective cohort

September 2017 to March 2018

*62.3

(SD: 15.5)

51.4%

72

Small: 33%:

Bulging: 28%

Long: 39%

Cannulation success

Saito et al.24

2022

Japan

3

Retrospective case–control

April 2012 to February 2020

*74.9

47.5%

1406

Haraldsson type I: 45%

Haraldsson type II: 44%

Haraldsson type III: 7%

Haraldsson type IV: 4%

Difficult cannulation

Thongsuwan et al.25

2021

Thailand

1

Retrospective cohort

January 2013 to May 2017

NA

50.4%

558

Haraldsson type I: 66%

Haraldsson type II: 16%

Haraldsson type III: 12%

Haraldsson type IV: 6%

Difficult cannulation

Cannulation failure

Post-ERCP pancreatitis,

Post-ERCP bleeding

Post-ERCP infection

Watanabe et al.26

2019

Japan

1

Retrospective cohort

September 2013 to June 2017

#70

36%

589

Regular protrusion: 12%

Small protrusion: 78%

Large protrusion: 10%

Annular pattern: 67%

Unstructured pattern: 7%

Longitudinal pattern: 7%

Isolated pattern: 1%

Gyrus pattern:16%

Unclassified pattern: 2%

Difficult cannulation

Cannulation failure

Cannulation attempts

Zhang et al.27

2016

China

1

Retrospective cohort

February 2012 to March 2015

*75 (SD: 2.2)

42.7%

82

bulging: 44%

normal: 22%

small: 16%

unusual location: 18%

Cannulation failure

Cannulation time

Zheng et al.28

2020

China

1

Retrospective cohort

January 2016 to December 2019

NA

46.1%

2385

others:18%

villous: 74%

granular: 8%

Post-ERCP pancreatitis