Table 2 Hazard ratios for all-cause mortality and cardiac mortality by categories of Troponin I (cTnI), in the German lung cancer screening trial (LUSI)¹.

From: Cardiac troponin I as predictor for cardiac and other mortality in the German randomized lung cancer screening trial (LUSI)

Troponin	n_{cases/controls}	Complete cohort
Troponin	n_{cases/controls}	HR (95% CI)	p_trend
Follow-up ≤ 5 years
Cardiac mortality³
Category 1 (< 6.0 ng/L) ref^¶	n = 13/2999
Category 2 (≥ 6–15 ng/L)	n = 5/461	1.69 (0.57–5.02)
Category 3 (≥ 16 ng/L)	n = 5/170	4.66 (1.73–12.50)	0.005
Categories 2 and 3 combined	n = 10/631	2.44 (1.06–5.61)	0.035
Troponin I ng/L (continuous)²	n = 23/3630	1.25 (1.05–1.49)	0.011
Mortality by all other causes (excluding cardiac mortality)
Category 1 (< 6.0 ng/L) ref^¶	n = 59/2953
Category 2 (≥ 6–15 ng/L)	n = 17/449	1.25 (0.72–2.16)
Category 3 (≥ 16 ng/L)	n = 7/168	1.56 (0.69–3.53)	0.209
Categories 2 and 3 combined	n = 24/617	1.64 (0.85–3.18)	0.253
Troponin I ng/L (continuous)²	n = 83/3570	1.09 (0.97–1.23)	0.134
Follow-up > 5–10 years
Cardiac mortality³
Category 1 (< 6.0 ng/L) ref^¶	n = 17/2995
Category 2 (≥ 6–15 ng/L)	n = 8/458	1.98 (0.73–5.33)
Category 3 (≥ 16 ng/L)	n = 3/172	1.66 (0.46– 5.97)	0.998
Category 2 and 3 combined	n = 11/630	1.88 (0.78–4.53)	0.156
Troponin I ng/L (continuous)²	n = 28/3625	1.10 (0.92–1.31)	0.264
Mortality by all other causes (excluding cardiac mortality)
Category 1 (< 6.0 ng/L) ref^¶	n = 142/2870
Category 2 (≥ 6–15 ng/L)	n = 33/433	1.09 (0.74–1.60)
Category 3 (≥ 16 ng/L)	n = 9/166	0.88 (0.45–1.74)	0.185
Categories 2 and 3 combined	n = 42/599	1.04 (0.73–1.47)	0.821
Troponin I ng/L (continuous)²	n = 184/3469	1.00 (0.91–1.09)	0.976
Full follow up time, up to max. 14.1 years
Cardiac mortality³
Category 1 (< 6.0 ng/L) ref^¶	n = 41/2971
Category 2 (≥ 6–15 ng/L)	n = 16/450	1.58 (0.84–2.96)
Category 3 (≥ 16 ng/L)	n = 10/165	2.71 (1.34–5.45)	0.004
Categories 2 and 3 combined	n = 26/615	1.88 (1.11–3.17)	0.017
Troponin I ng/L (continuous)²	n = 67/3586	1.15 (1.03–1.28)	0.014
Mortality by all other causes (excluding cardiac mortality)
Category 1 (< 6.0 ng/L) ref^¶	n = 278/2734
Category 2 (≥ 6–15 ng/L)	n = 71/395	1.15 (0.87–1.50)
Category 3 (≥ 16 ng/L)	n = 21/154	1.08 (0.70–1.71)	0.053
Categories 2 and 3 combined	n = 92/549	1.13 (0.89–1.44)	0.304
Troponin I ng/L (continuous)²	n = 370/3283	1.03 (0.97–1.09)	0.317

Significant values are in bold.
¹Based on competing risk models adjusted by age, sex, BMI, smoking history, stroke event, myocardial infarction event (previous or incident), hypertension (self-reported), coronary heart disease and diabetes.
²Continuous values were log₂ transformed.
³The following ICD 10 codes were included in cardiac mortality: I07.1, I11.0, I13.2, I21.0, I21.4, I21.9, I22.9, I25.1, I25.10, I25.5, I25.9, I42.0, I42.9, I46.1, I46.9, I48.9, I49.0, I49.9, I50.19, I50.9, I51.9
^¶Categories of cTnI, as defined by the following concentrations: < 6.0 ng/L, ≥ 6–15 ng/L, ≥ 16 ng/L.

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Table 2 Hazard ratios for all-cause mortality and cardiac mortality by categories of Troponin I (cTnI), in the German lung cancer screening trial (LUSI)¹.

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