Table 3 Evaluation of discrimination performance when adding troponin I to predict risk of cardiac mortality in the German randomized lung cancer-screening trial (LUSI).

From: Cardiac troponin I as predictor for cardiac and other mortality in the German randomized lung cancer screening trial (LUSI)

 

Log-likelihood ratio test

(χ2; df; p)

IDI-NRI (95% CI)*

AUC (%) 95% CI**

Cardiac mortality

 First 5 years of follow up (ncases = 23)

  (a) Model: age, sex, BMI and smoking history

  

70.5 (51.6–86.4)

  (b) Model a + cTnI (vs. Model a)

7.80; 1; 0.010

IDI: 0.005 (0.000, 0.024)

NRI: 0.278 (0.070, 0.486)

73.6 (58.1–87.3)

 First 10 years of follow up (ncases = 51)

  (a) Model: age, sex, BMI and smoking history

  

68.9 (57.6–79.7)

  (b) Model a + cTnI (vs. Model a)

11.4; 1; 0.003

IDI: 0.013 (0.002, 0.048)

NRI: 0.261 (0.100, 0.407)

70.0 (60.9–81.3)

 Entire follow up time (ncases = 67)

  (a) Model: Age, sex, BMI and smoking history

  

65.5 (53.8–74.5)

  (b) Model a + cTnI (vs. Model a)

12.56; 1; 0.001

IDI: 0.014 (0.003–0.049)

NRI: 0.226 (0.081–0.372)

66.6 (56.4–75.8)

  1. *Troponin I is included as a categorical variable (C1, C2, C3 categories).
  2. **Models were internally cross-validated on 1000 bootstrapped samples to correct for overfitting.
  3. IDI integrated discrimination index, NRI net reclassification index, AUC area under the receiver operator curve.
  4. p < 0.05.
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