Table 1 Clinical and demographical characteristics of the studied population.

From: Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population

Variables

Controls (n = 56)

Cases (n = 56)

p-value

CI95%

OR

Age

48 (59;23)†

48 (50;21)†

0.55

–

–

Male Sex

24 (42.8%)

35 (62.5%)

0.04*

1.04–4.74

2.22

Blood group

Group O

39 (69.6%)

40 (71.4%)

0.84

0.48–2.46

1.09

Group A

13 (23.2%)

14 (25.0%)

0.83

0.46–2.62

1.10

Group B

3 (5.3%)

2 (3.57%)

1

0.05–5.97

0.65

Group AB

1 (1.78%)

0 (0.0%)

1

0.00–39.00

0

Diagnostic test

RT-PCR

45 (80.4%)

55 (98.2%)

   

Antigen

10 (17.8%)

1 (1.8%)

   

Antibodies

1 (1.8%)

0 ()

   

Comorbidities

BMI*

26 (34;19)†

28.4 (50;19)†

 < 0.01*

0.69–4.19

–

Obesity

7 (12.5%)

17 (30.3%)

0.02*

1.15–8.09

3.05

Hypertension

8 (14.2%)

15 (26.7%)

0.1

0.85–5.70

2.20

T2DM*

3 (5.3%)

12 (21.4%)

0.02*

1.28–18.16

4.82

Cancer

3 (5.3%)

1 (1.78%)

0.62

0.03–3.19

0.32

Coronary artery disease

2 (3.57%)

1 (1.78%)

1

0.04–5.57

0.49

Arrythmia

1 (1.78%)

1 (1.78%)

1

0.06–16.39

1

Chronic kidney disease

0 (0.0%)

3 (5.3%)

0.24

–

–

HIV/Immunodeficiency

0 (0.0%)

1 (1.78%)

1

–

–

Autoimmune disease

0 (0.0%)

2 (3.57%)

0.5

–

–

Asthma

2 (3.57%)

2 (3.57%)

1

0.14–7.36

1

COPD*

0 (0.0%)

2 (3.57%)

0.5

–

–

Depression

0 (0.0%)

1 (1.78%)

1

–

–

Epilepsy/Seizures

1 (1.78%)

1 (1.78%)

1

0.06–16.39

1

Other comorbidities

24 (42.8%)

10 (17.8%)

 < 0.01*

0.12–0.69

0.29

Transplanted

1 (1.78%)

2 (3.57%)

1

0.18– 23.13

2.04

Smoking history

15 (26.7%)

20 (35.7%)

0.31

0.68–3.40

1.52

Active smoker

4 (7.14%)

3 (5.3%)

1

0.16–3.45

0.74

Number of cigarettes per day

0 (40;0)†

0 (70;0)†

0.72

–

–

Number of years smoking

0 (30;0)†

0 (40;0)†

0.55

–

–

Pack year*

0 (34;0)†

0 (52;0)†

0.75

–

–

Use of medication

35 (62.5%)

31(55.3%)

0.44

0.35–1.58

0.74

Chronic steroid use

1(1.78%)

2 (3.57%)

1

0.18–23.13

2.04

Number of comorbidities

0 (4;0)†

1 (5;0)†

 < 0.01*

–

–

No comorbidites

39 (69.6%)

21 (37.5%)

 < 0.01*

0.12–0.57

0.26

Inverse of no comorbidities

17 (30.3%)

35 (62.5%)

 < 0.01*

1.74–8.39

3.82

2 or more comorbidities

7 (12.2%)

15 (26.7%)

0.06

0.95–6.88

2.56

  1. *Statistically significant, p-value < 0.05; COPD, Chronic obstructive pulmonary disease; BMI, body mass index; Pack year , index that measures the amount smoked over a time period; CI, confidence intervals; OR, Odds ratio; RT-PCR, Reverse transcription polymerase chain reaction.
  2. † Variable that does not follow a normal distribution, its median was calculated (Sl Superior limit; Il Inferior limit).
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