Figure 5 | Scientific Reports

Figure 5

From: CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression

Figure 5

circGPC3 knockdown promotes HCC cell apoptosis. (A, B) Cell apoptosis was measured by flow cytometry in PLC/PRF/5 and Hep3B2.1-7 cells transfected with siRNAs. (C) Apoptosis in SK-HEP-1 cells was analyzed by flow cytometry when circGPC3 was upregulated. (D) Western blot analysis was performed to detect the protein levels of E-cadherin, N-cadherin, vimentin, Bax and Bcl-2 in PLC/PRF/5, Hep3B2.1-7 and SK-HEP-1 cells after circGPC3 knockdown or overexpression. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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