Figure 3
From: Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis
Proposed mechanism or pathophysiology of increased LH/FSH ratio in lean PCOS patients. Dynorphin from KNDy neurons increases the activity of GnRH neurons, increasing GnRH frequency, increasing LH secretion, and increasing the LH/FSH ratio. AMH produced by the ovaries affects GnRH neurons and increases the LH/FSH ratio. HOMA-IR will increase FAI, while FAI will increase AMH. Dot line: pathophysiology of increased LH/FSH ratio in lean PCOS patients. Red arrow: significant relationships found in this study. Black arrow: significant relationships found in other studies.
