Table 3 Detected SARS-CoV-2 mutations found in Helsinki, Viikinmäki WWTP wastewater samples between November 2021 and February 2022. The P-value of hypergeometric distribution when comparing found mutations to known mutations of the variants in the sample. When the p-value of the hypergeometric test was < 0.05, the variant was considered found. Underlining represents synonymous nucleotide mutations.

From: Detection of SARS-COV-2 variants and their proportions in wastewater samples using next-generation sequencing in Finland

Sampling start date

Number of all detected mutations

Delta B.1.617.2

Omicron BA.1

Omicron BA.2

Number of variant specific mutations 33

Number of variant specific mutations 37

Number of variant specific mutations 53

Number of detected variant specific mutations

p-value

Mutations found

Number of detected variant specific mutations

p-value

Mutations found

Number of detected variant specific mutations

p-value

Mutations found

8.11.2021

24

22

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, I82T, L452R, P1000L, P2287S, P681R, R203M, S26L, T120I, T19R, T3646A, T40I, V2930L, V82A

0

–

–

0

–

–

15.11.2021

23

23

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, S26L, T120I, T19R, T3646A, T40I, V2930L, V82A

0

–

–

0

–

–

22.11.2021

24

24

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, G662S, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, S26L, T120I, T19R, T3646A, T40I, V2930L, V82A

0

–

–

0

–

–

29.11.2021

30

22

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, T120I, T19R, T3646A, T40I, V2930L, V82A

0

–

–

0

–

–

7.12.2021

25

23

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G662S, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, S26L, T120I, T19R, T3646A, T40I, V2930L, V82A

0

–

–

0

–

–

12.12.2021

45

23

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, G662S, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, T120I, T19R, T3646A, T40I, V2930L, V82A,

13

< 0.0001

A2710T, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

1

0.9760

C26858T

20.12.2021

47

24

< 0.0001

A11332G, A1306S, A1918V, C8986T, D377Y, D63G, D950N, G210T, G215C, G662S, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, S26L, T120I, T19R, T3646A, T40I, V2930L, V82A

14

< 0.0001

A2710T, A27259C, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

0

-

-

3.1.2022

38

21

< 0.0001

A11332G, A1306S, C8986T, D377Y, D63G, D950N, G210T, G215C, I82T, L452R, P1000L, P2046L, P2287S, P681R, R203M, T120I, T19R, T3646A, T40I, V2930L, V82A

13

< 0.0001

A2710T, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

0

-

-

10.1.2022

36

15

< 0.0001

A11332G, A1918V, D377Y, D63G, D950N, G215C, I82T, L452R, P2046L, P681R, R203M, S26L, T120I, T40I, V82A

14

< 0.0001

A2710T, A27259C, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

0

-

-

17.1.2022

47

15

0.2372

A11332G, A1918V, D377Y, D63G, D950N, G215C, I82T, L452R, P2046L, P681R, R203M, S26L, T120I, T40I, V82A

13

< 0.0001

A2710T, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

8

0.3638

C12880T, C15714T, C22792T, D405N, G10447A, G1307S, R408S, S413R

24.1.2022

48

1

0.6245

A1918V

14

< 0.0001

A2710T, A27259C, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

17

< 0.0001

A9424G, C10198T, C15714T, C22792T, C26858T, D405N, G10447A, G1307S, L3027F, L3201F, R1315C, R408S, S135R, T223I, T3090I, T842I, V213G

31.1.2022

44

0

–

–

14

< 0.0001

A2710T, A27259C, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

13

0.0009

C12880T, C15714T, C22792T, C26858T, D405N, G10447A, G1307S, R408S, S413R, T19I, T223I, T842I, V213G

7.2.2022

32

0

–

–

11

< 0.0001

A2710T, A27259C, A67V, G446S, G496S, I3758V, K856R, L981F, T13195C, T5386G, T547K

4

0.5575

C12880T, C26858T, S413R, T223I

14.2.2022

49

1

0.9699

T40I

6

0.1024

A27259C, G496S, K856R, L981F, T13195C, T547K

14

0.0006

A9424G, C12880T, C26858T, G10447A, L3027F, L3201F, S135R, S413R, T19I, T223I, T3090I, T376A, T842I, V213G

21.2.2022

36

0

–

–

14

< 0.0001

A2710T, A27259C, A67V, C15240T, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T5386G, T547K

19

< 0.0001

A9424G, C10198T, C12880T, C15714T, C22792T, C26858T, D405N, G10447A, G1307S, L3201F, R1315C, R408S, S135R, S413R, T19I, T223I, T3090I, T842I, V213G

28.2.2022

27

0

–

–

11

< 0.0001

A2710T, A27259C, D3G, G446S, G496S, I3758V, K856R, L981F, N856K, T13195C, T547K

16

< 0.0001

C10198T, C12880T, C15714T, C22792T, C26858T, D405N, G10447A, L3201F, R1315C, R408S, S135R, S413R, T19I, T223I, T3090I, T842I

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