Table 1 Sensitivity analysis results of serum metabolites on sepsis and sepsis mortality within 28 days by MR-PRESSO, Cochrane’s Q test, and MR-Egger methods.

Outcome	Metabolite	Super-pathway	P_{Global_test}	P_{Heterogeneity}	P_Intercept
Sepsis	glucose	Carbohydrate	0.628	0.647	0.295
	heptanoate (7:0)	Lipid	0.627	0.579	0.934
	androsterone sulfate	Lipid	0.894	0.880	0.634
	propionylcarnitine	Lipid	0.400	0.383	0.718
	1-oleoylglycerophosphoethanolamine	Lipid	0.961	0.954	0.977
	X-14205-alpha-glutamyltyrosine	Peptide	0.837	0.807	0.678
	X-11787	Unknown	0.658	0.623	0.898
	X-12063	Unknown	0.725	0.644	0.275
	X-13435	Unknown	0.832	0.823	0.656
	salicylate	Xenobiotics	0.569	0.483	0.965
	saccharin	Xenobiotics	0.859	0.813	0.594
	metoprolol acid metabolite*	Xenobiotics	0.791	0.782	0.659
Sepsis (28 day death)	cotinine	Xenobiotics	0.579	0.541	0.466
	methionine	Amino acid	0.926	0.915	0.874
	4-acetamidobutanoate	Amino acid	0.423	0.393	0.527
	cysteine-glutathione disulfide	Amino acid	0.907	0.908	0.512
	3-(3-hydroxyphenyl)propionate	Amino acid	0.063	0.041	0.830
	glycocholate	Lipid	0.939	0.927	0.517
	taurochenodeoxycholate	Lipid	0.719	0.662	0.489
	3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF)	Lipid	0.817	0.746	0.759
	1-stearoylglycerophosphocholine	Lipid	0.855	0.826	0.475
	X-13183-stearamide	Lipid	0.657	0.639	0.436
	aspartylphenylalanine	Peptide	0.133	0.085	0.419
	gamma-glutamylphenylalanine	Peptide	0.400	0.405	0.871
	gamma-glutamylglutamate	Peptide	0.687	0.590	0.491
	X-11529	Unknown	0.576	0.420	0.170
	X-11538	Unknown	0.949	0.932	0.988
	X-11550	Unknown	0.306	0.278	0.194
	X-12465	Unknown	0.927	0.912	0.274
	X-13549	Unknown	0.189	0.179	0.534

Quick links

Search