Table 1 Clinical features, EEG and MRI findings, and histopathology.

From: Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study

CLINICAL FEATURES (n = 15)

   
 

Male, n (%)

 

9 (60%)

 

Age at MRI in y, median (IQR)

 

11.5 (2.0–13.7)

 

Age at epilepsy onset in y, median (IQR)

 

1.2 (0.3–5.8)

 

Epilepsy duration in y, median (IQR)

 

1.1 (0.8–4.5)

 

Seizure frequency

Seizure free*

5 (33%)

  

 < 30 seizures

5 (33%)

  

 ≥ 30 seizures

5 (33%)

 

History of status epilepticus, n (%)

 

5 (33%)

 

Sedation for MRI acquisition (n = 18), n (%)

 

10 (56%)

 

ASM at MRI (n = 18), n (%)

No ASM

3 (17%)

  

One ASM

6 (33%)

  

Two or more ASM

9 (50%)

EEG FINDINGS (n = 18)

 

Focal slowing, n (%)

 

11 (61%)

 

Spikes, n (%)

 

15 (83%)

 

Frequent spikes, n (%)

 

8 (44%)

MRI FINDINGS

Anatomical images (n = 15)

 

Left lateralisation, n (%)

 

8 (53%)

 

Lobar localisation, n (%)

Frontal

8 (53%)

  

Temporal

3 (20%)

  

Posterior

3 (20%)

  

Multilobar

1 (7%)

FCD volume (n = 18)

Lesion volume in mm3, median (IQR)

 

11,191 (1231–23,078)

Perfusion images (n = 18)

Perfusion pattern (n = 18)

 

Isoperfused, n (%)

 

2 (11%)

 

Hypoperfused, n (%)

 

10 (56%)

 

Hyperperfused, n (%)

 

6 (33%)

Perfusion extent (n = 16)

 

Larger, n (%)

 

9 (56%)

 

Equal, n (%)

 

7 (44%)

HISTOPATHOLOGY (n = 7)

  

FCD I

3 (43%)

  

FCD IIa

1 (14%)

  

FCD IIb

2 (29%)

  

FCD III$

1 (14%)

  1. We used per-patient analysis to detail the overall clinical features of the patients, and per-scan analysis to describe the respective EEG and MRI findings. Lobar involvement was classified as frontal, temporal, posterior, and multilobar. Lesions located in the parietal or occipital lobe were grouped as posterior, while lesions defined as multilobar involved more than one lobe, irrespective of the lobes involved.
  2. n: Number; FCD: Focal cortical dysplasia; MRI: Magnetic resonance; ASM: Anti-seizure medication; IQR: Inter-quartile range; Posterior: Involving either the parietal or the occipital lobe; *: Seizure free in the year before the MRI.