Figure 8

Mechanism of the BMAL1/REV-ERBα circadian rhythmic loop disruption in HF leading to fat expenditure. Disruption of the BMAL1/REV-ERBα circadian rhythmic loop leads to lipolysis of WAT, thermogenesis in beige/brown adipocytes, and inhibition of WAT production and storage, which is associated with excessive fat expenditure in HF.